Filyakova Vera Ivanovna

Position: Leading Researcher
Department: Laboratory of Heterocyclic Compounds
Phone: +7 (343) 3623321

Filyakova Vera Ivanovna - Doctor of Sciences, Professor, Leading Scientist of Institute of Organic Synthesis Ural Division of RAS

Filyakova V.I. graduated from the chemical-engineering department of Ural polytechnical institute (now Ural Federal University). In 1984 she defended PhD thesis on the theme: “Synthesis and the properties of the isomeric fluorine-containing b-aminovinylketones”. In 1999 Filyakova V.I. defended Doctor of chemical sciences thesis: “New polyfunctional fluorine-containing synthones: the methods of obtaining and synthetic possibilities”

 

Her scientific interests include development of the methods of synthesis, a study of competitory reactivity, the establishment of structure, a study of properties and the search for the areas of the practical application of the polyfunctional fluorine-containing compounds.

 

Filyakova V.I. with the co-authors have introduced into the practice of organic synthesis new chemically versatile fluorine-containing synthones: lithium enolates of b-diketones and of b-ketoesters.

 

The effective methods of obtaining the fluoroalkyl-containing mono-, bi- and polynuclear chelate complexes with the ions of transition metals, polyfunctional acyclic and heterocyclic compounds, including the linear and annelated systems of the cycles of different nature (derivatives of pyrazole, isoxazole, pyridine, pyrimidine, quinoline, 1,5-diazepine, phenanthridine, coumarine, the 1,8-naphthyridine, pyrazolo- and of triazolopyrimidine, triazolopyridazine, triazolocinnoline, imidazopyrimidine, imidazoquinazoline, furopyrazine) have been developed on their basis.

 

The distinctive features of the reactions of the 4-substituted thiosemicarbazides with fluorinated carboxylic acids and their ethers have been established (in comparison with the reactions  of the nonfluorinated analogs). The methods of the directed introduction of fluoroalkyl- and heteryl fragments into different positions of traizole and tiadiazole cycles have been developed. The new unusual reactions of fluoroalkyl-containing b-diketones, b-aminovinylketones, b-hydroxyketones, lithium enolates of b-diketones and b-ketoether have been found; in effect, the chemistry of fluoroalkyl-containing b-hydroxyketones has been actually created.

 

Some publications

 

• 1. E. F. Zhilina, P. A. Slepukhin, N. S. Boltacheva, M. G. Pervova, D. L. Chizhov, V. I. Filyakova, V. N. Charushin // Synthesis, structure and complexation of the fluorinated 1,3-enaminoketones containing at the nitrogen atom substituents with a terminal C≡C bond // Rus. J. General Chem.. 2012, Volume 82, Issue 12, pp 1962-1969.
• 2. E. F. Khmara, D. L. Chizhov, A. A. Sidorov, …, V.I. Filyakova,…// Synthesis, structure, electrochemical and magnetic properties of 2,6-bis(5-trifluoromethylpyrazol-3-yl)pyridine and its Ni^II complexes. // Rus. Chem. Bull., 2012, v.61, № 2.
• 3. Chizhov D.L., Pervova M.G., Samorukova M.A., Khmara E.F., Filyakova V.I., Saloutin V.I., Charushin V.N. // Trialkyl borate assisted amination of fluorinated 1,3-diketones for synthesis of N,N`-1,2-phenylen-bis(β-aminoenones) and their Ni (II), Cu(II) and Pg(II) complexes // J. Fluor. Chem. 2011. V. 132. № 6. P. 394-401.
• 4. D. L. Chizhov, E. F. Khmara, P. A. Slepukhin, V.I. Filyakova, V. N. Charushin. Structures of Ni(II), Pd(II) and Cu(II) complexes with 1,2-bis(5,5,5-trifluoro-4-oxopent-2-en-2-amino)benzene. // J Struct Chem., 2010, V. 51, №  2, P. 288-295
• 5. N. S. Boltacheva, V.I. Filyakova, E. F. Khmara, O. V. Koryakova, V. N. Charushin. // Synthesis and structure of fluoroalkyl containing lithium 1,3-diketonates. // Russ. J. General Chem., 2010, V. 80, №. 1, P. 179-189.
• 6. V.I. Filyakova, D. L. Chizhov, E. F. Khmara and V. N. Charushin. // Chelates of fluoroalkyl-containing enaminoketones. // Rus. J. General Chem., 2010, V. 80, № 1, P. 190-201.
• 7. V. I. Filyakova, N. S. Boltacheva, D. V. Sevenard, V.N. Charushin. // Reactions of fluoroalkyl-containing lithium 1,3-diketonates with diaminoarenes and 2-aminobenzenethiol. // Rus. Chem. Bull. , 2010, V. 59, № 9, P.  
• 8. D.V. Sevenard, O.G. Khomutov, N. S. Boltachova, V.I. Filyakova, V. Vogel, E. Lork, V. Ya. Sosnovskikh, V.O. Iaroshenko, G.-V. Röschenthaler // Metal and Boron Derivatives of Fluorinated Cyclic 1,3-Dicarbonyl Compounds // Z. Naturforsch. 2009, 64b, 541 –550.
• 9. N.S. Boltachova, O.V. Fedorova, I.G. Ovchinnikova, O.N. Kazheva, A.N. Chekhlov, O.A. Dyachenko, G.L. Rusinov, V.I. Filyakova, V.N. Charushin. // Fluorinated lithium 1,3-diketonates as reagents to modify podands and crown-ethers. // J. Fluor. Chem., 2007, № 128, P. 762.
• 10. E. B. Vasil′eva, V.I. Filyakova,  L. P. Sidorova, I. E. Filatov and V. N. Charushin. // Ambident Properties of 4-Substituted Thiosemicarbazides in Condensations with Fluoroacetic Acids. // Rus. J. Org. Chem., 2005, V. 41, № 10, P. 1522-1525.
• N. N. Mochul"skaya, A. A. Andreiko, M. I. Kodess, E. B. Vasil"eva and V. I. Filyakova, et al. Annelation of the thiazole ring to 1,2,4-triazines by tandem A_N—A_N or S_N^H—S_N^H reactions. Russian Chemical Bulletin, 2004, V. 53, № 6, P. 1279-1289.
• E. B. Vasil′eva, D. V. Sevenard, O. G. Khomutov, O. A. Kuznetsova, V.I. Filyakova, et al. // Synthesis of Trifluoroalkyl- and Fluoroaryl-Substituted 4,5-Dihydro-1H-1,2,4-triazole-5-thiones. // Rus. J. Org. Chem., 2004, V. 40, №  6, P. 874-878.
• V.N. Charushin, N.N. Mochulskaya, A.A. Andreiko, V.I. Filyakova, M.I. Kodess, O.N. Chupakhin // Aminovinyl ketones and amino-vinyl esters as the C-C-N building blocks for the synthesis of 1H-pyrrolo[3,2-e]1,2,4-triazines // Tetrahedron Letters, 2003, v. 44, No. 11, p. 2421-2424.
• O.A. Kuznetsova, V.I. Filyakova,  K.I. Pashkevich, E.N. Ulomskii, P.V. Plekhanov, et al. // Fluoroalkyl-containing lithium β-diketonates in the synthesis of 1,2,4-triazolo[1,5-a]pyrimidines. // Rus. Chem. Bull., 2003, V. 52, № 5, P. 1190-1194.
• N.S. Karpenko, V.I. Filyakova, E.G. Matochkina, M.I. Kodess, K.I. Pashkevich. // Synthesis of 6-fluoroalkylbenzo[h]cyclopenta[c]quinoline and -benzo[c]phenanthridine derivatives. // Rus. Chem. Bull., 2003, V. 52, № 5, P.1215-1216.
• V.I. Filyakova, O. A. Kuznetsova, E. N. Ulomskii, T. V. Rybalova, Yu. V. Gatilov, et al. // Synthesis of (7-polyfluoroalkyl)pyrazolo[1,5-a]pyrimidines based on lithium fluorine-containing β-diketonates. // Rus. Chem. Bull., 2002, V. 51, № 2, P. 332-336.
• V.I. Filyakova, N.S. Karpenko, O.A.Kuznetsova, K.I. Pashkevich // New fluorine-containing synthones - lithium salts of fluorine-containing b-diketones. // Zh. Org. Khim., 1998, v.34, № 3, p. 411-417. [Russ. J.Org.Chem., 1998 (Engl.Transl.)].
• K. I. Pashkevich, V.I. Filyakova, V. G. Ratner, O. G. Khomutov. // Polyfunctional fluoroalkyl-containing carbonyl compounds in the synthesis of heterocycles. // Rus. Chem. Bull., 1998, V. 47, № 7, P. 1239-1247.
•  V.I. Filyakova, V. G. Ratner, N. S. Karpenko, K. I. Pashkevich. // Interaction of fluoroalkyl-containing β-diketones with amines. // Rus. Chem. Bull., 1996, V. 45, № 9, P. 2163-2168.
• Pashkevich K.I., Filyakova V.I., Ratner V.G., Khomutov O.G. // New Polyfunctional Fluoroalkyl-containing Reagents. (Review). // Bashkirskii Khim. Zhurn. 1996. № 3. 93-106. (in Russian).
• Filyakova V.I., Ratner V.G., Khomutov O.G., Pashkevich K.I. // Formation and Possibilyties of Using of Polyfunctional Fluorocontaining Compounds. // Zhur. Org. Khim. 1994. V.30. P.1833-1837 (in Russian).
• A.V. Kutchin, O.G. Khomutov, V.I. Filyakova, K.I. Pashkevich // Alanes in Synthesis of Fluorinated compounds // J.Fluor. Chem. Vol 54. 1991. P. 219.
• V.I. Filyakova, D. S. Yufit, Yu. T. Struchkov, K. I. Pashkevich. // Crystal structure of 1,1,1,2,2-pentafluoro-3-aminohex-3-en-5-one and isomerization of β-aminovinylketones and β-aminovinylthiones containing fluorine. // Rus. Chem. Bull., 1990, V 39, № 5, P 936-939.
• K.I. Pashkevich, V.I. Filyakova, V.G. Ratner, R.R. Latypov // Polyfluoroalkyl-containing a,b-epoxy-and a,b-aziridineketones // The Sixth Regular Meeting of Soviet-Japanese Fluorine Chemists. The Society of Synthetic Organic Chemistry, Japan. Section H. 1989. P.1-14. 
• V.I. Filyakova, K. I. Pashkevich. // Exchange reaction between fluorine-containing β-diketones and β-aminovinylketones. // Rus. Chem. Bull., 1989, V. 38, № 1, P.203.
• V.I. Filyakova, I.G. Busygin, K. I. Pashkevich. // Isomerization of fluorine-containing β-aminovinyl ketones and β-aminovinylthyones // Zh. Org. Khim., 1987, V.25, № 9, P. 1865-1867. [Russ. J.Org.Chem., 1987 (Engl.Transl.)].
• V.I. Filyakova, K. I. Pashkevich and I. Ya. Postovskii. // Isomerization of fluorine-containing β-aminovinyl ketones. // Rus. Chem. Bull., 1981, V. 30, № 11, P. 2207.
• K. I. Pashkevich, V.I. Filyakova // Interaction of fluorine-containing β-aminovinyl ketones with amines. // Rus. Chem. Bull., 1986, V. 35, № 3, P. 566-570

 

Patents of the U.S.S.R. and the Russian Federation:

•  K. I. Pashkevich and V.I. Filyakova, I. Ya. Postovskii, A.G. Kechina, S.P.Krukovskii, A.A.Jarosch, V.A.Ponomarenko // Copper chelates of polyfluorinated β-aminovinylketones as the catalysts of the trimerization of perfluorocarboxylic acids nitriles into the triazines // Patent SSSR 763346. 
• V.I. Filyakova, A.L. Kotel′nikova, R.R. Latypov, K. I. Pashkevich. // Method of obtaining of fluorine-containing α,β-usaturated ketones // Patent SSSR 1419095. V. G. Ratner, V.I. Filyakova, K. I. Pashkevich // Method of obtaining of fluoroalkyl-containing α,b-epoxyketones // Patent SSSR 1504987.
• V.I. Filyakova, V. G. Ratner, O.G. Khomutov, K. I. Pashkevich // Method of obtaining of fluoroalkyl-containing β-hydroxyketones // Patent SSSR 1779013.
• A.V. Kutchin, V.I. Filyakova, O.G. Khomutov, K. I. Pashkevich, G.A. Tolstikov // Method of obtaining of secondary fluorinated alcohols // Patent SSSR 1754700.
• O.G. Khomutov, V.I. Filyakova, K. I. Pashkevich // Method of obtaining of fluoroalkyl-containing a,b-aziridineketones // Patent Rus.Fed. 2054416.
• V. G. Ratner, O.G. Khomutov, V.I. Filyakova, N. S. Karpenko, K. I. Pashkevich // Method of obtaining of fluoroalkyl-containing b-diketones // Patent Rus.Fed. 2100345.